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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8313 | HCH6-1 | Others | |
HCH6-1 is a competitive Formyl peptide receptor 1 (FPR1) antagonist. | |||
T40423 | L48H37 | ||
L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio... | |||
T0610 | Piceatannol | trans-Piceatannol,Astringenin | Apoptosis , Serine/threonin kinase , PKA , Syk , PKC , Autophagy |
Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is... | |||
T3409 | Plantamajoside | Y0160,C10485 | Others |
Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity. | |||
T6986 | Sivelestat | ONO5046,EI546,LY544349 | Others , SARS-CoV , Serine Protease |
Sivelestat (ONO5046) is a potent and selective inhibitor of neutrophil elastase with IC50 of 44 nM. | |||
T2663 | GTS-21 dihydrochloride | GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine | 5-HT Receptor , AChR |
GTS-21 dihydrochloride (DMBX-anabaseine) is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh. | |||
T2870 | Matrine | Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine | Mitophagy , Ferroptosis , Opioid Receptor , Autophagy |
Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. | |||
TP1016L | Aviptadil Acetate | Vasoactive Intestinal Peptide acetate salt | RAAS , SARS-CoV |
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmona... | |||
T6S0105 | Peiminine | Zhebeinone,Fritillarine,Raddeanine,Verticinone | Others , Autophagy |
1. Peiminine (Raddeanine) is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury. | |||
T5798 | Euphorbia Factor L2 | euphorbiafactor L2 | Apoptosis , NF-κB |
Euphorbia Factor L2 alleviates lipopolysaccharide-induced acute lung injury and inflammation through inhibits NF-κB activation. | |||
T4S1422 | Praeruptorin E | Others , Calcium Channel | |
1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit... | |||
T39719 | Nrf2 activator-1 | Nrf2 activator-1 | Nrf2 |
Nrf2 activator-1 is a potent activator of NF-E2-related factor 2 (Nrf2).Nrf2 activator-1 can be used to study COPD and other respiratory diseases including asthma, acute lung injury (ALI), acute respiratory distress synd... | |||
T40612 | Manganese(salen) chloride | EUK-8 | Others |
Manganese(salen) chloride (EUK-8) (EUK-8) is a superoxide dismutase and catalase mimetic. Manganese(salen) chloride (EUK-8) is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates a... | |||
T77582 | Anti-inflammatory agent 51 | NF-κB | |
Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative col... | |||
T3S0401 | Piceatannol 3'-O-glucoside | Piceatannol 3-glycoside,Quzhaqigan | Arginase , NO Synthase |
Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury. | |||
T3676 | Sesamol | 1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol | Apoptosis , AMPK |
Sesamol (1,3-Benzodioxol-5-ol) could decrease lung inflammation and lipopolysaccharide (LPS)-induced lung injury in rats. Sesamol ameliorates inflammatory and oxidative damage by upregulating AMPK activation and Nrf2 sig... | |||
T38404 | MJ33 lithium salt | ROS | |
MJ33 lithium salt is an inhibitor of NADPH oxidase type 2-mediated ROS generation, a fluorinated phospholipid analog that inhibits the phospholipase A2 (PLA2) activity of peroxiredoxin 6 (Prdx6), and is used in the study... | |||
T3902 | Atractylenolide III | ICodonolactone,8β-Hydroxyasterolide | Apoptosis |
Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung... | |||
TN1936 | Mogroside III-E | IL Receptor , TNF , TLR | |
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis... | |||
T20762 | Sivelestat sodium tetrahydrate | ONO-5046 sodium tetrahydrate,Elaspol,ONO 5046,ONO5046 sodium tetrahydrate,Elaspol sodium tetrahydrate,ONO-5046,Sivelestat Sodium,Sivelestat Sodium Hydrate,ONO5046 | Serine Protease |
Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for... |